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Physical resilience indicators derived from haemodynamic signals in older adults : relation to cognitive status, cognitive decline and surgical outcome

Klop, M. (2020) Physical resilience indicators derived from haemodynamic signals in older adults : relation to cognitive status, cognitive decline and surgical outcome.

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Abstract:Background: Assessing physical resilience, the ability to bounce back after a stressor, provides insight in an individual’s recovery potential. A resilient person recovers faster, and shows smaller, more random fluctuations in rest than a less resilient person. Aim: Investigating quantitative resilience measures in haemodynamic signals, related to cognition and surgical outcome. Methods: Orthostatic blood pressure (BP) and cerebral perfusion recovery were determined and related to one-year cognitive change in 29 elderly with mild cognitive impairment (MCI). Dynamical indicators of resilience (DIORs; temporal autocorrelation (TAC) and variance) were derived from resting BP measurements in 50 AD patients, 31 older adults with MCI and 41 healthy elderly, during sitting and standing. Ultimately, resilience measures were implemented at the outpatient clinic, including patients prior to thoracic aortic surgery. Results: Diminished orthostatic BP recovery was associated with cognitive decline. TAC tended to be higher in AD patients, while both DIORs were higher during standing than sitting, and not related to cognitive decline. Clinical implementation was feasible, with an inclusion of 27 patients until now. Conclusion: Our results, partially relating cognition and resilience, suggest that challenging the body may enhance differences in resilience. At preoperative assessment, an orthostatic challenge can be an easy resilience tool.
Item Type:Essay (Master)
Faculty:TNW: Science and Technology
Subject:44 medicine
Programme:Technical Medicine MSc (60033)
Link to this item:http://purl.utwente.nl/essays/83167
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