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Intra-operative SPES : the influence of propofol on local brain networks in epilepsy patients

Blok, Sifra (2021) Intra-operative SPES : the influence of propofol on local brain networks in epilepsy patients.

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Abstract:Single Pulse Electrical Stimulation (SPES) can be performed in epilepsy patients with subdural electrocorticography (ECoG). We want to perform SPES in the operating room (OR). Perform SPES in the OR would make the need to wait for seizures during the intensive monitoring week redundant. The anaesthetic propofol causes a prolongation of the actions of the inhibitory populations. An NMM might explain the change in ERs appearance caused by the inhibitory effect of propofol. A retrospective analysis determined that a subset of two stimuli per stimulation pair instead of ten stimuli resulted in similar cortico-cortical networks. A prospective analysis showed that performing intra-operative SPES is feasible and that similar functional connectivity of electrodes was found. With the analysis of a computational model, we determined that adaptations of the inhibitory populations suffice to invoke the experimentally observed effect of propofol on an ECoG response.
Item Type:Essay (Master)
Clients:
UMC Utrecht, Utrecht, The Netherlands
Faculty:TNW: Science and Technology
Subject:44 medicine
Programme:Technical Medicine MSc (60033)
Link to this item:http://purl.utwente.nl/essays/86081
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