Artificial Intelligence (AI) is beginning to emerge in the realm of music, a crucial medium in the creation and communication of meaning acting as a form of cultural transmission. This study uses a historical mode of analysis to establish the socio-cultural significance of music by looking at its interwoven nature with cultural movements of the 20th century, and investigates how the advent of varying AI technologies in music will affect the meaningfulness of music and its practices of meaning-making as well as the impact this will have on contemporary culture, informed through a critical mode of analysis using Jean Baudrillard’s theories relating to simulacra, simulation, and hyperreality. AI voice filters, deepfakes, and generative models produce music that constitute simulacra, inducing a state of hyperreality wherein it is becoming increasingly difficult to distinguish the simulated from the real. The meaningfulness of music is likely to collapse due to this hyperreality along with the oversaturation and homogenization of music produced through the use of AI technologies. The replicative nature of generative AI models is likely to lead to a lack of uniqueness and diversity among musical expressions and may potentially lead to the disruption and death of the historical flow of popular culture as understood traditionally.