In recent years the concept of Industry 5.0 has become a growing topic. Industry 5.0 can be considered as the fifth industrial revolution and improves on the current Industry 4.0, which was introduced in 2011 in Germany. Since 2021, the industry has been transitioning towards Industry 5.0, in which the importance of environmental and social aspects is highlighted. Furthermore, it is important to note that Industry 5.0 is not a technology-driven revolution. In the context of the manufacturing industry, Industry 5.0 intends to reshape the industry into a more human-centric, sustainable, and resilient industry. This study researches the impact of Industry 5.0 on the skillset and leadership style of middle managers within the manufacturing industry in the Netherlands. In order to reach this goal, this study has conducted qualitative research in the form of a multiple-case study. This study has conducted semi-structured interviews for gathering data from middle managers in manufacturing organizations in the Netherlands. This data has been analyzed using the Gioia methodology and forms the basis of the results of this study. Based on the gathered results, this study has found that Industry 5.0 requires middle managers to improve on several types of skills: technical skills, coaching skills, green thinking skills, and energy & waste management skills. Furthermore, this study has found that Industry 5.0 requires middle managers to adopt more empathetic and situational leadership because employees are all different and have different expectations of leadership. Therefore, the leadership style must be fitted toward employees instead of adopting one style of leadership for all employees.