pH Sensing and Antibody detection with Surface Functionalized ISFETs

This Master Thesis project explores the multifaceted potential of Ion Sensitive Field-Effect Transistors (ISFETs) in the area of peptide synthesis monitoring and biomolecule detection. By investigating the FETs suitability for the in situ pH tracking during peptide synthesis, this project aims to enhance the precision of biochemical processes. Furthermore, the study explores the detection of target biomolecules, specifically Antibodies, with the prospective goal of evaluating their affinity to peptide sequences. These advancements can contribute greatly to the integration of nano-FET technology into a cutting-edge platform that will assist the selection of neo-antigens for cancer vaccines within the framework of the ”ElectroMed” project.