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Quantification of aerosol deposition in the nasal cavity

Scheeren, Mark (2024) Quantification of aerosol deposition in the nasal cavity.

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Abstract:Nasal sprays are currently used to administer local medication for congestion and allergies. Utilizing both high vascularization and nose-to-brain pathways allows for broader medication administration. To leverage these capabilities, Medspray developed a soft mist nasal spray. Quantifying aerosol deposition is essential for evaluating nasal spray effectiveness and investigating volume distribution. Using the fluorescent properties of calcein, photo analysis was able to quantify volume and surface area by calibrating the emission intensity to the deposition's thickness. The algorithm calculated the volume of deposition with approximately 20% deviation. The traditional swirl nozzle deposited 85% of the volume on a surface area of 80 mm², while the soft mist nozzle deposited 73% on a surface area of 148 mm². The remaining 15% and 27% were spread over surface areas of 1766 mm² and 2082 mm², respectively. The developed algorithm can quantify aerosol dispersion, providing insight into volume distribution in the nasal cavity. Artefacts during calibration and measurement were shown to affect accuracy. Photo analysis allowed for the quantification of aerosol deposition in the nasal cavity. It also demonstrates the Swirl nozzle creates larger droplets over a smaller surface area when compared to the Soft Mist nozzle.
Item Type:Essay (Master)
Clients:
Medspray. B.V., Enschede, Netherlands
Faculty:TNW: Science and Technology
Subject:33 physics, 44 medicine, 52 mechanical engineering, 54 computer science
Programme:Biomedical Engineering MSc (66226)
Link to this item:https://purl.utwente.nl/essays/100220
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