University of Twente Student Theses
Investigating the difference in uremic toxin removal between single-pass and recirculation dialysis experiments, using in-house filters
Roos, J.C.G. (2023) Investigating the difference in uremic toxin removal between single-pass and recirculation dialysis experiments, using in-house filters.
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| Abstract: | For patients with chronic kidney disease (CKD) haemodialysis therapy is an often life-saving therapy which can replace the filtering capacities of the kidney. Although this therapy is mostly effective, it also greatly reduces the autonomy of patients. The patients have to be treated at the hospital multiple times a week for multiple hours. One important reason for this is the need of a large dialysis volume by current dialysis machines, making it very difficult to treat the patient at home. This study is concentrated on the improvement of current haemodialysis therapy, focusing on the usage of a smaller dialysate volume and investigating the influence on the effectiveness of the therapy. To do this, several experiments have been carried out using a smaller dialysate volume and a small-scale haemodialysis set-up. The current single-pass dialysis system, using a large amount of dialysate volume, is compared to a recirculation dialysis system, which reuses a smaller amount of dialysate. Experiments with the toxins creatinine, hippuric acid (HA) and indoxyl sulfate (IS) have successfully been carried out. A small-scale Convergence set-up has been used in combination with in-house made modules with Fresenius FX1000 fibers and human plasma spiked with toxins. Measurements of four hours have been carried out and at different moments samples of the plasma and dialysate have been taken. The total removal after four hours, the clearance/dialysance and the toxin concentrations over time have been calculated using the obtained toxin concentrations. The creatinine measurements showed better removal by the single-pass system, compared to the recirculation system. The decrease in creatinine concentration in the plasma and the total removal of creatinine by the single-pass system were more efficient, compared to the recirculation system. This difference was significant. For the HA measurements the single-pass system showed a slightly better decrease of HA after four hours, however due to the large standard deviation this difference was not significant. This was also the case for the total removal of HA. For the IS measurements both systems showed similar removal. Due to the standard deviation being relatively large, no conclusion can be given about which system was more effective. However, the HA and IS results show that for these toxins the removal by the two different systems is very similar. |
| Item Type: | Essay (Bachelor) |
| Faculty: | TNW: Science and Technology |
| Subject: | 42 biology, 44 medicine |
| Programme: | Biomedical Technology BSc (56226) |
| Link to this item: | https://purl.utwente.nl/essays/101796 |
| Export this item as: | BibTeX EndNote HTML Citation Reference Manager |
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