University of Twente Student Theses
Design and testing of a breast perfusion tumor phantom for dynamic contrast-enhanced Computed Tomography
Gouma, Sanne (2024) Design and testing of a breast perfusion tumor phantom for dynamic contrast-enhanced Computed Tomography.
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| Abstract: | Breast cancer is the most prevalent cancer among women, accounting for 25% of all cancer diagnoses worldwide. Early and reliable detection and monitoring techniques are essential for effective treatment. This study focuses on Dynamic Contrast-Enhanced dedicated Breast Computed Tomography (DCE-bCT). The aim is to develop a tumor phantom combined with an existing breast phantom and an optical spectrometer setup to evaluate DCE-bCT as a potential monitoring technique for breast cancer. 3D printing methods, including fused deposition modelling (FDM) and stereolithography (SLA), were used to fabricate the phantoms. The tumor phantom was designed to mimic the complex vascular structures of tumors, incorporating small gyroid structures (pores sizes of 1.3 and 1.5 mm), internal channels (0.8 - 1 mm diameter) and leaking vessels. To ensure air-free phantoms, the proper filling technique and running fluid composition (49.5% water, 49.5% glycerol and 1% Ilfotol), were investigated, and results were evaluated with cone beam CT. Three final phantom designs were tested using DCE-bCT after they fulfilled all the requirements. Each of the final phantoms featured at least two distinct regions that created different flow patterns, designated as regions of interest (ROIs). For each ROI, a time-intensity curve (TIC) was planned to be generated, allowing intraphantom comparisons to assess the distinguishability of ROIs using DCE-bCT. The phantoms designed in this study were compatible with the setup. Flow was successfully passed through the phantom without air being trapped inside. The optical spectrometer data showed the expected wash-in and wash-out pattern created. Due to uncontrollable circumstances, no time-intensity curves have been created for the different tumor phantom designs. The results of the tumor phantom research and the DCE-bCT breast cancer monitoring method can be verified by interpreting the curves later on. |
| Item Type: | Essay (Bachelor) |
| Faculty: | TNW: Science and Technology |
| Subject: | 44 medicine |
| Programme: | Biomedical Technology BSc (56226) |
| Link to this item: | https://purl.utwente.nl/essays/103583 |
| Export this item as: | BibTeX EndNote HTML Citation Reference Manager |
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