University of Twente Student Theses

Login

Development of a fibroglandular tissue phantom for testing and validation of dynamic contrast enhanced dedicated breast CT

Mom, Marthe (2024) Development of a fibroglandular tissue phantom for testing and validation of dynamic contrast enhanced dedicated breast CT.

[img] PDF
18MB
Abstract:Dynamic contrast-enhanced dedicated breast computed tomography (DCE-bCT) is a new imaging modality for diagnosis, treatment planning and response monitoring of breast cancer. To validate and optimise the acquisition and reconstruction parameters for this modality, a fibroglandular tissue perfusion phantom is being developed. After contrast administration in the anatomical breast the tumour enhances, but so does the fibroglandular tissue, a process called background parenchyma enhancement (BPE). Therefore, the aim of this study is to develop a BPE phantom. The BPE phantom also contains a tumour with a diameter of 18mm. Static 3D images and dynamic angiography images were made using the Siemens Artis Pheno C-arm. Time-intensity curves of five regions of interest (ROIs) in the phantom were created from dynamic X-ray images. Particular focus was given to the comparison of the tumour ROI and the fibroglandular tissue ROIs. The time-intensity curves showed promising results, as the tumour ROI shows a significant higher intensity during enhancement than the fibroglandular tissue ROI, which is equivalent to the shape of the iodine concentration curves of a tumour and fibroglandular tissue in patients. The developed fibroglandular tissue perfusion can be used as a tool for the validation of dynamic contrast enhanced dedicated breast CT.
Item Type:Essay (Bachelor)
Faculty:TNW: Science and Technology
Subject:44 medicine
Programme:Biomedical Technology BSc (56226)
Link to this item:https://purl.utwente.nl/essays/104822
Export this item as:BibTeX
EndNote
HTML Citation
Reference Manager

 

Repository Staff Only: item control page