University of Twente Student Theses
The role of coronary plaque volumes in major adverse cardiovascular events
Dasselaar, S.G.W. (2025) The role of coronary plaque volumes in major adverse cardiovascular events.
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| Abstract: | Introduction. Coronary computed tomography angiography (CCTA) is a non-invasive imaging technique for assessing coronary artery disease (CAD). It provides detailed images of coronary arteries, enabling detection and characterization of atherosclerotic plaques. This study investigates the relationship between coronary plaque volumes identified through CCTA and the occurrence of major adverse cardiovascular events (MACE), as well as factors affecting plaque volume measurements. Methods.This retrospective study included patients who underwent CCTA at Iisala Hospital between January 2019 and December 2021. Patients with incomplete or unassessable scans were excluded. Propensity score matching created two comparable groups: 63 patients with MACE and 63 without. Plaque volumes were measured using GE AW-server software. Statistical analyses included Mood’s median test and the Mann-Whitney U test to compare plaque volumes between groups. Results. A total of 126 patients were analyzed after matching, with no significant baseline differences (p > 0.05). Plaque volume trends suggested higher overall volumes in the MACE group. No statistical differences in plaque volume were found between the no MACE and MACE group. Non-calcified (<30 HU) and fibro-fatty (31–130 HU) plaque volumes were larger in the MACE group. Calcified plaque volumes (>350 HU) were smaller in the MACE group. Conclusion. While no significant differences in plaque volumes were observed, trends indicate larger non-calcified and fibro-fatty plaque volumes in the MACE group and smaller calcified plaque volumes. |
| Item Type: | Essay (Master) |
| Clients: | Isala, Zwolle, Nederland |
| Faculty: | TNW: Science and Technology |
| Subject: | 44 medicine |
| Programme: | Technical Medicine MSc (60033) |
| Link to this item: | https://purl.utwente.nl/essays/104879 |
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