University of Twente Student Theses
Removing barriers for lactate quantification in the portal vein using deuterium metabolic imaging
Wennemars, G.W.D. (2025) Removing barriers for lactate quantification in the portal vein using deuterium metabolic imaging.
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| Abstract: | Introduction: Chronic mesenteric ischemia (CMI) results from reduced mesenteric blood flow. Its diagnosis is challenged by nonspecific symptoms and large morphological variability. Detecting lactate via 2H-MRSI in the portal vein could serve as a function test but may be affected by respiratory motion. This study assesses the impact of the current practice of non-gated acquisition on spectral quality, linewidth, signal-to-noise ratio, Cramér-Rao Lower Bounds and repeatability of quantification. Moreover, stomach-induced ghosting is simulated and suppressed in a phantom. Methods: The impact of respiratory motion on spectra was investigated in the liver using 31P-MRSI at 7T. Gated free breathing, non-gated free breathing and non-gated deep breathing scans were compared. Ghosting was investigated using a phantom simulation with a moving acetone container as surrogate for the stomach using 1H-MRSI at 1.5T. Results: No clear difference was found between gated and non-gated free breathing acquisitions. Deep breathing consistently performed worse in every aspect. Ghosting artifacts were successfully simulated and suppressed with a REST-slab-suppressive sequence. Impact: This study found no evidence that non-gated acquisition negatively affects liver MRSI in free breathing. Moreover, ghosting reduction appears feasible. Further research is required to confirm the applicability of these findings for 2H-MRSI in the portal vein. |
| Item Type: | Essay (Master) |
| Clients: | UMC Utrecht, Utrecht, The Netherlands |
| Faculty: | TNW: Science and Technology |
| Subject: | 44 medicine, 50 technical science in general |
| Programme: | Biomedical Engineering MSc (66226) |
| Link to this item: | https://purl.utwente.nl/essays/105428 |
| Export this item as: | BibTeX EndNote HTML Citation Reference Manager |
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