University of Twente Student Theses
Experimental Investigation of Photobiomodulation Therapy for Wound Healing: Assessing its Therapeutic Potential
Gabriël, BSc. Alexandros A.V. (2025) Experimental Investigation of Photobiomodulation Therapy for Wound Healing: Assessing its Therapeutic Potential.
|
PDF
1MB |
| Abstract: | Photobiomodulation therapy (PBMT) has gained some traction in recent years as a non-invasive treatment method for wound healing, however there is no widespread adoption in clinical settings. This shortcoming is mainly due to the incomplete understanding of the related molecular mechanisms as well as the therapeutic potential of PBMT. This study aims to validate the beneficial effects of PBMT on wound healing and gain a further understanding of the cellular processes involved. Using cell line of human dermal fibroblasts (HDFs), THP-1 monocytes, and primary human skin cells, we were able to systematically study the effects of PBMT on cell viability, contractility and migration. Furthermore, collagen and α-smooth muscle actin (α-SMA) expression, as well as gene and protein expressions of factors related to extracellular matrix (ECM) remodeling and inflammation were investigated. |
| Item Type: | Essay (Master) |
| Faculty: | TNW: Science and Technology |
| Subject: | 02 science and culture in general, 30 exact sciences in general, 42 biology, 44 medicine, 50 technical science in general |
| Programme: | Biomedical Engineering MSc (66226) |
| Link to this item: | https://purl.utwente.nl/essays/106216 |
| Export this item as: | BibTeX EndNote HTML Citation Reference Manager |
Show download statistics for this publication
Show download statistics for this publicationRepository Staff Only: item control page