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On-chip separation of spermatozoa using dielectrophoresis

Eijkeren, C.E. van (2011) On-chip separation of spermatozoa using dielectrophoresis.

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Abstract:The aim of the fertility project in the BIOS group of the University of Twente is to develop a portable point of care semen quality analyzer. This should enable couples who are staying unwanted childless to perform semen quality tests themselves in a convenient environment. The quality of semen depends on four important factors, these are the concentration, motility, viability and morphology. This master thesis is focused on the separation of spermatozoa based on their motility and viability. The research described in this thesis was focused on the possibility to separate motile and non-motile spermatozoa and to separate viable and non-viable spermatozoa on-chip with a technique called dielectrophoresis. Based on theory, simulations were performed, resulting in six different lab-on-a-chips are designed that have been manufactured. Measurements with boar-semen were performed to verify the simulations and to measure the sorting functioning of these chips. It was not possible to test the separation operation of the chip, due to experimental problems and the limited time available. However, some of the simulation results were confirmed by the experiments. More research is necessary to investigate the separation of spermatozoa.
Item Type:Essay (Bachelor)
Faculty:EEMCS: Electrical Engineering, Mathematics and Computer Science
Subject:53 electrotechnology
Programme:Electrical Engineering BSc (56953)
Link to this item:http://purl.utwente.nl/essays/69580
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