University of Twente Student Theses


Stimulus related evoked potentials around the nociceptive detection threshold

Berg, B. van den (2018) Stimulus related evoked potentials around the nociceptive detection threshold.

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Abstract:The neural processing of pain stimuli can be studied using EEG by estimation of the evoked potential using the averages of large sets of trials. However, the maximum number of stimuli in experiments to gather the required data on human subjects is limited. Often, stimulus selection methods are used for a more efficient probing of the stimulus parameter space. However, this results in different amounts of trials per stimulus property, which is problematic for conventional averaging. An analysis method which is robust to variations in the amount of trials is provided by a linear mixed model. It is demonstrated that for multi-stimulus EEG data the quality of an evoked potential estimate is improved by using a linear mixed model, which effectively deals with correlation between stimulus parameters and enables us to study stimulus-related brain activity at the subject-level and group-level simultaneously. This brings us one step closer to the development of objective diagnostics based on brain activity.
Item Type:Essay (Master)
Faculty:EEMCS: Electrical Engineering, Mathematics and Computer Science
Subject:44 medicine, 50 technical science in general, 54 computer science
Programme:Electrical Engineering MSc (60353)
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