University of Twente Student Theses


The introduction of foetal therapy for TTTS patients in the Radboudumc : including the development of 3D FLOVA-SLAM

Jeltes, Claire (2018) The introduction of foetal therapy for TTTS patients in the Radboudumc : including the development of 3D FLOVA-SLAM.

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Abstract:The twin-twin transfusion syndrome (TTTS) occurs in 20% of the monochorionic pregnancies and results from unbalanced foeto-foetal blood transfusion between the twins through placental anastomoses. Fetoscopic laser occlusion of vascular anastomoses (FLOVA) is commonly used to treat TTTS. Although, FLOVA is commonly used in the field of foetal therapy, it is characterized by the disadvantage of a small field of view of the fetoscope during the procedure. This can lead to a difficulty in orientation and navigation for the surgeon. The first objective of this research was to implement FLOVA in the Radboudumc and to create the second invasive foetal therapy centre of the Netherlands. The second aim of this project was to overcome the problems of the limited field of view during FLOVA by implementing a method that can provide a real-time 3D overview map of the placental vascular topography. Years of preparation, were followed by the introduction of the FLOVA procedure in the Radboudumc in January this year. Hereby, the Radboud now is the referral centre for the eastern part of the Netherlands. Furthermore, a framework for the 3D FLOVA-SLAM software has been developed. 3D FLOVA-SLAM is based on the recently developed ORB-SLAM and is used to generate a real-time textured 3D reconstruction of the placenta. The first results of using 3D FLOVA-SLAM on placental videos are promising, indicating that our approach has a high chance of success to address the urgent problem of the limited field of view during FLOVA procedures. The hypothesis is that, with the real-time map of the placenta, surgeons can use smaller diameter instruments during the procedure and hereby reduce the associated risks and complications, like pregnancy loss. Furthermore, we expect that a better orientation for the surgeon will lead to a faster procedure, shorter learning curves and improved accuracy leading to lower risk of complications.
Item Type:Essay (Master)
Radboudumc, Nijmegen, Nederland
Radboudumc, Nijmegen, Nederland
Faculty:TNW: Science and Technology
Subject:44 medicine, 54 computer science
Programme:Technical Medicine MSc (60033)
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