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Improving adherence by guiding inhalation via electronic monitoring in children with uncontrolled asthma (IMAGINE-I) : a preliminary analysis

Eikholt, A.A. (2021) Improving adherence by guiding inhalation via electronic monitoring in children with uncontrolled asthma (IMAGINE-I) : a preliminary analysis.

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Abstract:Asthma control is the degree to which manifestations and symptoms of asthma are reduced or removed by therapy. Asthma control failure is commonly due to poor therapy adherence and improper inhalation technique. Adherence and inhalation technique were monitored by recording vibration patterns during inhalations. This data could be converted into immediate personalised smart feedback on inhalation medication. This study aims to evaluate whether asthma control could be improved in children between 6 and 18 years old by providing immediate smart feedback on inhalation medication. The degree of asthma control was measured using four categories: Forced Expiratory Volume in 1 second (FEV1), (Childhood) Asthma Control Test ((c-)ACT) score, reversibility and lung function variability (LFV). The interaction of the two groups and the mean change over time for the four categories were assessed with mixed model repeated measures analysis with fixed effects. Data were analysed for sixteen randomised children. This preliminary analysis showed no significant difference in all outcome measures to prove that providing immediate smart feedback to children improved the degree of their asthma control compared to the control group. However, most of the children showed clinically relevant improvement over the entire study duration despite the allocated group.
Item Type:Essay (Master)
Faculty:TNW: Science and Technology
Subject:44 medicine
Programme:Health Sciences MSc (66851)
Link to this item:https://purl.utwente.nl/essays/87573
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