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Computational modelling of flow in the liver vasculature using the Lattice Boltzmann method to study microsphere distribution

Hoek, Jan van der (2021) Computational modelling of flow in the liver vasculature using the Lattice Boltzmann method to study microsphere distribution.

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Abstract:Radioembolization is a non-ablative selective procedure that is used for the treatment of advanced stage liver cancer and liver metastases. In this procedure, radioactive microspheres are administered to blood flow in the liver arteries by catheter injection, which embolize in narrower vessels near the malignant tissue. More insight into microsphere distribution and factors that could influence this can improve radioembolization and enhance patient lives. To study the microsphere distribution in the vasculature, the Lattice-Boltzmann method is used to study flow in a simplified model of the right hepatic artery. The Lattice-Boltzmann method is a CFD based method that originates from statistical mechanics, in which a version of the Boltzmann transport equation is solved. The general flow distribution is predicted in this study by analysing the flow behaviour during the cardiac cycle. A foundation is laid for future research on the behaviour and distribution of some particle distributions can already be predicted using simulations. Next to the flow behaviour analysis, a qualitative study into catheter injection has been conducted by analysing the impact of catheter angle and injection location. Preliminary results show promising results on the impact catheter injection can have on radioembolization outcomes.
Item Type:Essay (Master)
Faculty:ET: Engineering Technology
Subject:33 physics, 44 medicine, 52 mechanical engineering
Programme:Mechanical Engineering MSc (60439)
Link to this item:http://purl.utwente.nl/essays/88308
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