University of Twente Student Theses


Performance of handheld probes for Sentinel lymph node detection

Mir, N (2021) Performance of handheld probes for Sentinel lymph node detection.

[img] PDF
Abstract:Background: Sentinel Lymph Node Biopsy (SLNB) paves an efficient way of resecting Lymph nodes (LNs ) with highest chance of containing potential metastases. While avoiding unnecessary , complication laden procedures, it is imperative that this procedure is reliable. In case of Floor of Mouth (FoM) tumors, shinethrough phenomenon impacts the visibility and localization of individual nodes, especially those in proximity to the tumor/injection site. Hence , in FoM , SLNBs have not reported very successful results and there is a need to address this gap. With the introduction of Superparamagnetic Iron oxide nanoparticles (SPIONs) the usage of radioactive tracers , the current standard can be avoided. However, it is not known if magnetic handheld probes , i.e., DiffMag and Sentimag® provide efficient solutions for SLNB in FoM tumors. Method: In this study, the detection depth and resolving power of magnetic handheld probes DiffMag is compared to Sentimag® and gamma probe , Europrobe 3.2. Magtrace and 99mTc are the tracers used. Results: The detection depth was determined to be 10 mm, 17mm for Sentimag®, and 12 mm, 19 mm for DiffMag (for 140 µg Fe and 2800µg Fe Magtrace respectively). In comparison the detection depth of Europrobe extends to >120mm and >170 mm( for ≈5.75MBq and ≈23MBq 99mTc). At 25mm DiffMag and Sentimag® were able to detect two samples (140 µg Fe and 2800µg Fe Magtrace) as separate sources, whereas Europrobe was not able to determine the location of sources clearly at this distancer. Conclusion: DiffMag handheld probe is a better choice for clinical application in FoM SLNB procedures as compared to Sentimag® and Europrobe. The detection depth of DiffMag is sufficient for SLNB procedures while the resolving power is better than Europrobe. Although the resolving power of DiffMag and Sentimag is comparable, DiffMag can lead to faster and less complicated handling in comparison to Sentimag® due to its non-linear magnetic detection mechanism.
Item Type:Essay (Master)
Radboud University Medical Center, Nijmegen, Netherlands
Faculty:TNW: Science and Technology
Subject:33 physics, 42 biology
Programme:Biomedical Engineering MSc (66226)
Link to this item:
Export this item as:BibTeX
HTML Citation
Reference Manager


Repository Staff Only: item control page