University of Twente Student Theses


Light fluence marker for quantitative photoacoustic imaging

Weernink, C.J.H. (2022) Light fluence marker for quantitative photoacoustic imaging.

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Abstract:Carotid atherosclerosis is a disease in which the carotid artery narrows down due to plaque formation. Photoacoustic imaging is a promising technique for providing information about the plaque composition. In this research, it is studied if photoacoustic imaging can be used to obtain the absorption spectrum of an unknown absorber. Furthermore, the relation between the concentration of the chromophore and the resulting photoacoustic signal is investigated. This study is based on a hypothesis that a known absorber can be used to correct for the difference in light propagation at different wavelengths, to retrieve the absorption spectra of an unknown chromophore. In the experiment, two tubes containing a solution of India Ink are examined. The tubes are examined with multiple wavelengths of light and the measured PA signals of one tube are compensated for the differences in the signal from the other tube, which has a constant, known concentration ink. The resulting photoacoustic signal follows the absorption spectrum of India Ink. The relation between the photoacoustic signal and the concentration of the chromophore is not linear proportional. Looking at the amount of signal coming from across the tube might give an indication about the light fluence at that particular depth.
Item Type:Essay (Bachelor)
Faculty:TNW: Science and Technology
Subject:33 physics, 44 medicine, 50 technical science in general
Programme:Biomedical Technology BSc (56226)
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