University of Twente Student Theses


Development of a phantom set-up for perfusion quantification in X-ray imaging modalities

Goris, Liselot (2022) Development of a phantom set-up for perfusion quantification in X-ray imaging modalities.

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Abstract:Purpose: The ultimate goal of this research is to facilitate ground-truth evaluation of image-derived tissue perfusion measures in the clinical setting. This work focuses on the development of a perfusion phantom set-up dedicated to angiographic imaging of the microcirculation in the lower extremities and computed tomography (CT) perfusion imaging of the brain. Methods: This study contains the design, realisation and testing of the phantom set-up. The phantom is designed for 3-D printing and comprises a vessel structure which branches into two microcirculation compartments that can be filled with a material of choice. The interchangeable phantom is build into a flow circuit in which the flow can be controlled and measured with flow sensors, a perfusion defect can be simulated by adjusting the resistance. The reproducibility, effect of a perfusion defect, effect of flow velocity, effect of imaging protocol and effect of imaging system was tested on two different C-arm CT imaging systems. Proof of concept tests were performed with multidetector CT for perfusion imaging and the associated clinical software. Results: With the phantom set-up realistically shaped and reproducible time-intensity curves (TICs) were acquired in 2-D perfusion imaging, small standard deviations in time-intensity variables between repeated experiments (<4.4%) were observed. Imaging system specific features were found to be negatively affecting the intensity variables, reducing the reliability of the imaging technique for perfusion quantification based on intensity values. In the CT perfusion measurements TICs were obtained with the clinical software, the calculated flow and volume were directly related and a promising correlation between the computed and measured flow was found (ρ = -0.98, p=0.01). However, the shape and values of the TICs do not resemble the values of human cerebral perfusion data yet. Conclusions: versatile perfusion phantom set-up applicable for 2-D perfusion angiography imaging is designed and realised. With small changes the set-up could be suitable for multi-modality and multi-disease purposes and may provide necessary insights in perfusion imaging techniques.
Item Type:Essay (Master)
Faculty:TNW: Science and Technology
Subject:44 medicine
Programme:Biomedical Engineering MSc (66226)
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