University of Twente Student Theses
The development and evaluation of a novel, non-invasive measuring system for the prevention of diabetic ketoacidosis.
Bos, D.M. (2023) The development and evaluation of a novel, non-invasive measuring system for the prevention of diabetic ketoacidosis.
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| Abstract: | Introduction: A potentially life-threatening complication of diabetes is diabetic ketoacidosis (DKA). The measurement of ketones can be an important tool in preventing DKA. Current technologies do not meet the requirements to be used by diabetic patients in the daily practice. A new sensor, called the PuppyNose, has been developed for the continuous non-invasive measurement of ketones on the skin. It is the goal of this thesis to help the PuppyNose progress through different stages of the research and development process. Methods: During four sub-studies the technical feasibility of the device is evaluated. The device is tested in-vitro and in-vivo in participants under normal physiological conditions and in a participant who is in a state of ketosis. Results: Laboratory testing has shown that the PuppyNose gave an accurate and linear representation of acetone concentrations in a range of 1 to 100 ppm with a limit of detection at 0.5 ppm. In contrast to this, the sensor demonstrated a decreasing sensor response as a result of humidity and low inter-observer and test re-test reliabilities. During an in-vivo fasting experiment (n=1) no significant correlation was found between the VOC-output of the device and fasting beta−HB levels rising to 1.7 mmol/L. Conclusion: The PuppyNose in its current form is not able to a clinically useful measuring device. The device should be fundamentally redesigned in order to have a successful impact in predicting the risk of DKA. |
| Item Type: | Essay (Master) |
| Faculty: | TNW: Science and Technology |
| Subject: | 44 medicine, 53 electrotechnology |
| Programme: | Biomedical Engineering MSc (66226) |
| Link to this item: | https://purl.utwente.nl/essays/94485 |
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