University of Twente Student Theses
A trade study of biohybrid microrobots: comparing actuation and localization of ironsperm
Bloxs, Mohan (2023) A trade study of biohybrid microrobots: comparing actuation and localization of ironsperm.
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| Abstract: | In recent years, untethered biohybrid microrobots have shown great promise for in vitro magnetic actuation and localization using medical imaging techniques. One type of untethered biohybrid microrobots is IRONSperm cells, which consist of dead bovine sperm cells coated with Iron Oxide nanoparticles that allow for magnetic actuation and enhance localization using ultrasound imaging. When increasing the Iron Oxide concentration, a trade-off occurs between the magnetic actuation, ultrasound localization, and the biocompatibility of IRONSperm clusters. To date, it was unknown how an increase in Iron Oxide concentration affected this trade-off. The aim of this study is to investigate the influence of an increasing concentration of Iron Oxide nanoparticles on the actuation and localization of IRONSperm clusters. This influence is determined by actuating different IRONSperm samples at increasing frequencies and imaging them with ultrasound. For the actuation, the average angular velocity of the different samples will be determined and for the localization, the ultrasound contrast-to-noise ratio will be determined. It is found that the angular velocity and contrast to noise ratio increase with increasing Iron Oxide concentration but because the cluster size of the different samples also differed, it cannot be concluded that the increase in angular velocity and contrast to noise ratio depend solely on the Iron Oxide concentration increase. Investigating the influence of Iron Oxide concentration will help to determine the optimal consistency of IRONSperm clusters for future research toward in vivo applications. |
| Item Type: | Essay (Bachelor) |
| Faculty: | ET: Engineering Technology |
| Programme: | Biomedical Technology BSc (56226) |
| Link to this item: | https://purl.utwente.nl/essays/95742 |
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