University of Twente Student Theses
Development of a bladder phantom of materials which can be analysed by OCT and a miniature camera for the next-gen in-vivo project
Beek, E.J.A. van (2023) Development of a bladder phantom of materials which can be analysed by OCT and a miniature camera for the next-gen in-vivo project.
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| Abstract: | To improve bladder cancer diagnostics, the Next gen in-vivo project is creating a robot that analyses bladder tissue with optical coherence tomography (OCT) and a miniature camera. A bladder phantom is developed for ex-vivo experiments in the Next gen in-vivo project. OCT is used to visualise possible bladder tumours and the bladder wall. The bladder wall consists of the urothelium, lamina propria and muscularis propria. A miniature camera is used to create a 3D reconstruction of the bladder. The bladder phantom can be analysed with these imaging techniques. Furthermore, the phantom includes blood vessels and tumour sites of the CIS, Ta, T1 and T2 tumours. Materials and Methods: The techniques sandwich molding and spin coating were used to create the three layers of the bladder wall. A spin coater was developed. Samples were developed to determine which materials were suitable to use in phantoms. Based on the OCT images of the samples, the phantoms were made from Dragon skin and TiO2. Furthermore, tumours with their characteristics can be created using these materials and analysed with OCT. Different kinds of inks to create blood vessels were tested to determine their influence on the OCT images. Eventually, blood vessels were created using red permanent marker. OCT images of the samples and phantoms and camera images of the second phantom were obtained. Results: Using sandwich molding and spin coating together with the materials Dragon skin and TiO2, it is possible to create the three layers of the bladder that can be distinguished with OCT. With these materials the tumours CIS, Ta, T1 and T2 could be developed with certain characteristics and transitions. Conclusion: To create a bladder phantom with tumours, Dragon skin and TiO2 were the materials that were most suitable to work with OCT and a miniature camera. The ratio for TiO2 for the bladder layers are 0.06: 0.21: 0.15 %w/w for the urothelium, lamina propria and muscularis propria respectively. Furthermore, sandwich molding and spin coating were the most suitable techniques. |
| Item Type: | Essay (Bachelor) |
| Faculty: | EEMCS: Electrical Engineering, Mathematics and Computer Science |
| Subject: | 01 general works |
| Programme: | Biomedical Technology BSc (56226) |
| Link to this item: | https://purl.utwente.nl/essays/96374 |
| Export this item as: | BibTeX EndNote HTML Citation Reference Manager |
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