University of Twente Student Theses
The perioperative occurrence of hypoxia and the balance between oxygen supply and demand in aortic arch surgery patients
Veen, K. van der (2024) The perioperative occurrence of hypoxia and the balance between oxygen supply and demand in aortic arch surgery patients.
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| Abstract: | The mismatch between the supply and demand of oxygen in the brain can lead to postoperative neurological dysfunction. Perioperative multimodal monitoring could provide insight into cerebral oxygen balance and multiple processes influencing cerebral blood flow. We conducted an observational study to assess perioperative oxygen balance. Regional and global saturation, cerebral blood flow velocity, cerebral activity, and vital signs were recorded. Within patients, differences in the supply and demand parameters between hypoxia and normoxia were observed. Differences in performance of autoregulation and neurovascular coupling were also assessed by calculatingmean flow index, correlation between EEG and TCD and by transfer function analysis. We included four patients who underwent aortic arch surgery between May and October 2022. Hypoxia was registeredin 50% (2/4) of patients. In one patient, both hypoxic and normoxic saturation levels were measured. CBFV and high-frequency EEG powers were lower under hypoxia than under normoxia. Moments of impaired autoregulation were observed in hypoxia.Analysis ofneurovascular coupling wasinconclusive. Hypoxia can occur postoperatively. Conclusions about the progressionof oxygen balance cannot be drawn due to missing data. The lowered flow and lowered activity in hypoxia suggest an oxygen imbalance. Future studies should focus on recording efficiency. |
| Item Type: | Essay (Master) |
| Faculty: | TNW: Science and Technology |
| Subject: | 44 medicine, 50 technical science in general |
| Programme: | Technical Medicine MSc (60033) |
| Link to this item: | https://purl.utwente.nl/essays/98960 |
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